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Walker Jackson

Associate Professor, Docent

I study how specific brain regions are targeted in various neurodegenerative diseases.

Selective Vulnerability to Neurodegenerative Diseases

We use mouse genetic tools to understand how specific brain regions are affected by neurodegenerative processes.

We also are interested in understanding how poor sleep affects the onset and progression of neurodegenerative disease. We address these problems by developing models of diseases and tools to study them. One of our main technical focuses in recent years is to study how gene regulation in specific cell types is affected by neurodegenerative disease and sleep loss, using genetically encoded tools and next generation sequencing techniques. Manipulation of gene sequence and activity with CRISPR/Cas based methods is also a strength of the lab.

News

people in a lab.

Neurodegeneration can be studied long before symptoms arise

In prion diseases, the brain gradually deteriorates. New research suggests that cellular changes can be studied extremely early in the disease process, which is important if we are to develop treatments.
People mingling at Building 511, Campus US.

The WCMM-LiU symposium highlights crucial topics in medical science

Researchers from LiU, Sweden and invited international scientists, will give talks focusing on a broad range of topics around science, medicine, and technology. The WCMM-LiU symposium is an opportunity to network, interact, and share ideas.

Research

Illustration of various diseased centers in the brain.

Selective vulnerability to neurodegeneration

Neurodegenerative diseases cause stereotypical signs based on the specific brain region that is targeted. We try to understand how unaffected regions resist disease with the hope that these secrets can be transferred to vulnerable brain regions.

Related Research

Image of molecules that will take you to WCMM's homepage.

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Publications

Publications in DiVA

2025

Chwen-Yu Chen, Lech Kaczmarczyk, Felipe Meira de Faria, Marcin Szczot, Walker Jackson, Max Larsson (2025) Scientific Reports, Vol. 15, Article 10890 (Article in journal)
Farjana Parvin, Johan Larsson, Walker Jackson, Sofie Nyström, Per Hammarström (2025) Journal of Molecular Biology, Vol. 437, Article 168923 (Article in journal)
Hamza Arshad, Shehab Eid, Surabhi Mehra, Declan Williams, Lech Kaczmarczyk, Erica Stuart, Walker Jackson, Gerold Schmitt-Ulms, Joel C. Watts (2025) Neurobiology of Disease, Vol. 206, Article 106802 (Article in journal)

2024

Surabhi Mehra, Matthew E. C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Hamza Arshad, Jennifer K. Griffin, Kathy L. Frost, Daniel J. Walsh, Surachai Supattapone, Stephanie A. Booth, Walker Jackson, Joel C. Watts (2024) Journal of Clinical Investigation, Vol. 134, Article eI176344 (Article in journal)
Maria Immaculata Arifin, Samia Hannaoui, Raychal Ashlyn Ng, Doris Zeng, Irina Zemlyankina, Hanaa Ahmed-Hassan, Hermann M. Schatzl, Lech Kaczmarczyk, Walker Jackson, Sylvie L. Benestad, Sabine Gilch (2024) PLoS Pathogens, Vol. 20, Article e1012350 (Article in journal)
Paul R. Marshall, Joshua Davies, Qiongyi Zhao, Wei-Siang Liau, Yujin Lee, Dean Basic, Ambika Periyakaruppiah, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Marcin Kielar, Arie Maeve Brueckner, Hao Gong, Haobin Ren, Alexander Walsh, Lech Kaczmarczyk, Walker Jackson, Alon Chen, Robert C. Spitale, Timothy W. Bredy (2024) Journal of Neuroscience, Vol. 44, Article e0093232024 (Article in journal)
Daniel J. Walsh, Judy R. Rees, Surabhi Mehra, Matthew E. C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Walker Jackson, Joel C. Watts, Surachai Supattapone (2024) PLoS Pathogens, Vol. 20, Article e1012087 (Article in journal)
Walker Jackson, Susanne Bauer, Lech Kaczmarczyk, Srivathsa Magadi (2024) Biology, Vol. 13, Article 67 (Article, review/survey)

2023

Sonia M. Vallabh, Dan Zou, Rose Pitstick, Jill OMoore, Janet Peters, Derek Silvius, Jasna Kriz, Walker Jackson, George A. Carlson, Eric Vallabh Minikel, Deborah E. Cabin (2023) Journal of Virology, Vol. 97 (Article in journal)
Maria I. Arifin, Lech Kaczmarczyk, Doris Zeng, Samia Hannaoui, Chi Lee, Sheng Chun Chang, Gordon Mitchell, Debbie McKenzie, Michael Beekes, Walker Jackson, Sabine Gilch (2023) Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Article e2221060120 (Article in journal)
Hedayat Rahin, Walker Jackson, Magnus Thordstein (2023) Brain Sciences, Vol. 13, Article 229 (Article in journal)
Susanne Bauer, Chwen-Yu Chen, Maria Jonson, Lech Kaczmarczyk, Srivathsa Magadi, Walker Jackson (2023) Acta neuropathologica communications, Vol. 11, Article 17 (Article in journal)
Walker Jackson (2023) Neural Regeneration Research, Vol. 18, p. 2707-2708 (Article in journal)

2022

Lech Kaczmarczyk, Melvin Schleif, Lars Dittrich, Rhiannan H. Williams, Maruša Koderman, Vikas Bansal, Ashish Rajput, Theresa Schulte, Maria Jonson, Clemens Krost, Fabio J. Testaquadra, Stefan Bonn, Walker S. Jackson (2022) PLoS Pathogens, Vol. 18, Article e1010747 (Article in journal)
Susanne Bauer, Lars Dittrich, Lech Kaczmarczyk, Melvin Schleif, Rui Benfeitas, Walker Jackson (2022) Life Science Alliance, Vol. 5, Article e202201530 (Article in journal)
Alana M. Thackray, Brian Lam, Erin E. McNulty, Amy V Nalls, Candace K. Mathiason, Srivathsa Magadi, Walker Jackson, Olivier Andreoletti, Cristobal Marrero-Winkens, Hermann Schätzl, Raymond Bujdoso (2022) Brain, Vol. 145, p. 3236-3249 (Article in journal)
Patrick Leven, Reiner Schneider, Kevin D. Siemens, Walker Jackson, Sven Wehner (2022) Neurogastroenterology and Motility, Vol. 34, Article e14309 (Article in journal)

2021

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguiere, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel (2021) Neurobiology of Disease, Vol. 158, Article 105473 (Article in journal)
Lech Kaczmarczyk, Nicole Reichenbach, Nelli Blank, Maria Jonson, Lars Dittrich, Gabor C. Petzold, Walker Jackson (2021) Scientific Reports, Vol. 11, Article 5412 (Article in journal)

2020

Stefanie Poll, Manuel Mittag, Fabrizio Musacchio, Lena C. Justus, Eleonora Ambrad Giovannetti, Julia Steffen, Jens Wagner, Lioba Zohren, Susanne Schoch, Boris Schmidt, Walker S. Jackson, Dan Ehninger, Martin Fuhrmann (2020) Nature Neuroscience, Vol. 23, p. 952-958 (Article in journal)

Organisation

The Division of Cell and Neurobiology (CNB)

The Division of Cell and Neurobiology is a dynamic and innovative environment where we conduct research and teaching on both the structure and function of various cells as well as the nervous system and sensory organs.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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