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Integrative Systems Biology (ISB)

In the integrative systems biology group we aim towards being the world leading group in the unravelling of systems-level mechanistic insights, using inter-connected M4 models for decision support in pharma and P4 medicine – thereby making a positive change in society.

We do modelling in collaboration with a large number of experimental groups, focusing on different biological systems. In these projects, our collaborators serve as the biological experts, and we are the experts on the modelling. This means that our collaborators do not need to have extensive knowledge about modelling.

We are currently working on modelling of e.g. insulin signalling and lipolysis in adipocytes; nutrient fluxes on a whole-body scale; interpretation of fMRI signals in brain, and quantification of liver- and heart-diseases using MRI; modelling as an aid for improved drug development; and modelling to replace animal experiments.

In the systems biology group, we are constantly looking for new collaborations; be it students for internships, experimentalists for new projects or companies for making our insights of use for the public. Feel free to contact us if you want to know more!

Current projects

Finished projects

Publications

2024

Christian Simonsson, Elin Nyman, Peter Gennemark, Peter Gustafsson, Ingrid Hotz, Mattias Ekstedt, Peter Lundberg, Gunnar Cedersund (2024) Clinical Nutrition, Vol. 43, p. 1532-1543 (Article in journal)

2023

Niloofar Nikaein, Kedeye Tuerxun, Gunnar Cedersund, Daniel Eklund, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Dirk Repsilber, Alexander Persson, Elin Nyman (2023) Journal of Biological Chemistry, Vol. 299, Article 105205 (Article in journal)
Christian Simonsson, William Lövfors, Niclas Bergqvist, Elin Nyman, Peter Gennemark, Karin G. Stenkula, Gunnar Cedersund (2023) Biochemical engineering journal, Vol. 191, Article 108798 (Article in journal)
William Lövfors, Rasmus Magnusson, Cecilia Jönsson, Mika Gustafsson, Charlotta S. Olofsson, Gunnar Cedersund, Elin Nyman (2023) npj Systems Biology and Applications, Vol. 9, Article 24 (Article in journal)
Tilda Herrgårdh, Christian Simonsson, Mattias Ekstedt, Peter Lundberg, Karin G. Stenkula, Elin Nyman, Peter Gennemark, Gunnar Cedersund (2023) Diabetology & Metabolic Syndrome, Vol. 15, Article 250 (Article in journal)

2022

William Lövfors, Cecilia Jönsson, Charlotta S. Olofsson, Elin Nyman, Gunnar Cedersund (2022)

2021

William Lövfors, Jona Ekström, Cecilia Jönsson, Peter Strålfors, Gunnar Cedersund, Elin Nyman (2021) PLOS ONE, Vol. 16, Article e0261681 (Article in journal)
William Lövfors, Christian Simonsson, Ali M. Komai, Elin Nyman, Charlotta S. Olofsson, Gunnar Cedersund (2021) Journal of Biological Chemistry, Vol. 297, Article 101221 (Article in journal)
Tilda Herrgårdh, Hao Li, Elin Nyman, Gunnar Cedersund (2021) Frontiers in Physiology, Vol. 12, Article 619254 (Article in journal)

2020

Elin Nyman, Maria Lindh, William Lövfors, Christian Simonsson, Alexander Persson, Daniel Eklund, Erica Backstrom, Markus Friden, Gunnar Cedersund (2020) CPT: Pharmacometrics and Systems Pharmacology (PSP), Vol. 9, p. 707-717 (Article in journal)

Latest student publications

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Christian Simonsson (2018)
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Victor Viberg (2018)
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Teodor Erngren (2017)

Group leader

Organisation