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Integrative Systems Biology (ISB)

Research group for Integrative systems biology (ISB) at Linköping University.

In the integrative systems biology group we aim towards being the world leading group in the unravelling of systems-level mechanistic insights, using inter-connected M4 models for decision support in pharma and P4 medicine – thereby making a positive change in society.

We do modelling in collaboration with a large number of experimental groups, focusing on different biological systems. In these projects, our collaborators serve as the biological experts, and we are the experts on the modelling. This means that our collaborators do not need to have extensive knowledge about modelling.

We are currently working on modelling of e.g. insulin signalling and lipolysis in adipocytes; nutrient fluxes on a whole-body scale; interpretation of fMRI signals in brain, and quantification of liver- and heart-diseases using MRI; modelling as an aid for improved drug development; and modelling to replace animal experiments.

In the systems biology group, we are constantly looking for new collaborations; be it students for internships, experimentalists for new projects or companies for making our insights of use for the public. Feel free to contact us if you want to know more!

Current research projects

Finished projects

Publications

2025

Wile Balkhed, Martin Bergram, Fredrik Iredahl, Markus Holmberg, Carl Edin, Carljohan Carlhäll, Tino Ebbers, Pontus Henriksson, Christian Simonsson, Karin Rådholm, Gunnar Cedersund, Mikael Forsgren, Olof Dahlqvist Leinhard, Cecilia Jönsson, Peter Lundberg, Stergios Kechagias, Nils Dahlström, Patrik Nasr, Mattias Ekstedt (2025) Journal of Internal Medicine (Article in journal)
Alejandro Garcia-Rudolph, Sergiu Albu, Mark Andrew Wright, Maria del Mar Laya, Claudia Teixido, Eloy Opisso, Gunnar Cedersund, Montserrat Bernabeu (2025) Archives of Physical Medicine and Rehabilitation, Vol. 106, p. 729-737 (Article in journal)
Belén Casas Garcia, Kajsa Tunedal, Federica Viola, Gunnar Cedersund, Carljohan Carlhäll, Matts Karlsson, Tino Ebbers (2025) Scientific Reports, Vol. 15, Article 1352 (Article in journal)
Alejandro Garcia-Rudolph, Mark Andrew Wright, Claudia Teixido, Eloy Opisso, Gunnar Cedersund, Josep Medina (2025) BRAIN IMPAIRMENT, Vol. 26, Article IB24032 (Article in journal)

2024

Nina Grankvist, Cecilia Jönsson, Karin Hedin, Nicolas Sundqvist, Per A Sandström, Bergthor Björnsson, Arjana Begzati, Evgeniya Mickols, Per Artursson, Mohit Jain, Gunnar Cedersund, Roland Nilsson (2024) Nature Metabolism, Vol. 6, p. 1963-1975 (Article in journal)
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Mullers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Lofmark, Carina Ammala, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilen (2024) Communications Biology, Vol. 7, Article 877 (Article in journal)
Christian Simonsson, Elin Nyman, Peter Gennemark, Peter Gustafsson, Ingrid Hotz, Mattias Ekstedt, Peter Lundberg, Gunnar Cedersund (2024) Clinical Nutrition, Vol. 43, p. 1532-1543 (Article in journal)
Gustav Magnusson, Maria Engström, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Anders Tisell (2024) Frontiers in Medicine, Vol. 11, Article 1352012 (Article in journal)
Henrik Podéus, Christian Simonsson, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Peter Lundberg, William Lövfors, Gunnar Cedersund (2024) npj Digital Medicine, Vol. 7, Article 112 (Article in journal)

2023

Niloofar Nikaein, Kedeye Tuerxun, Gunnar Cedersund, Daniel Eklund, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Dirk Repsilber, Alexander Persson, Elin Nyman (2023) Journal of Biological Chemistry, Vol. 299, Article 105205 (Article in journal)

Latest student publications

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Christian Simonsson (2018)
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Victor Viberg (2018)
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Teodor Erngren (2017)

Research group

Organisation