91视频

Akademiska erfarenheter

2021- G盲stprofessor, Link枚pings universitet
2018- Professor emeritus, School of Biological Sciences, Nanyang Technological University, Singapore
2014-2018 Professor, till盲mpad biokemi (bioteknik), Biologiska institutionen, Nanyang Technological University, Singapore
2012-2014 Lee Wee Nam g盲stprofessor, Nanyang Technological University, Singapore
2010-2013 Professor, till盲mpad biokemi (bioteknik), Linn茅universitetet
1999-2010 Professor, till盲mpad biokemi (bioteknik), Kalmar universitet

Industriella erfarenheter

2018- Bioentrepreneur, AffiSten
Tretton 氓rs industriell erfarenhet som entrepren枚r och ledare f枚r FoU (1980-1993).
Grundare av fyra Life Science-f枚retag (Perstorp Biolytica AB, KalBiotech AB, ProLiff AB och Transientic Interactions AB).

鲍迟尘盲谤办别濒蝉别谤

Jag fick det prestigefyllda ISMR-priset 2017 f枚r affinitetsteknologier som administrerades av International Society for Molecular Recognition. Denna utm盲rkelse 盲r en av de fr盲msta som kan erh氓llas inom forskning om biologiska interaktioner och deras till盲mpningar.

Forskningsintressen

F枚rst氓 rollen och vikten av svaga och 枚verg氓ende interaktioner i biologisk igenk盲nning och deras till盲mpningar i klinisk diagnostik och l盲kemedelsutveckling. Utveckla det transienta l盲kemedelskonceptet, kontinuerliga biosensorer, biologiska imprinting tekniker och svag affinitetskromatografi (WAC; Affinity LC/MS) f枚r farmaceutiska och diagnostiska applikationer.

Nyckelkompetenser

• Analytisk biokemi, s盲rskilt kromatografi, elektrofores, immunanalyser, masspektroskopi (MS),
  biosensorteknik (SPR), spektroskopi (inklusive fluorescens och ultraviolett)
• Proteinvetenskap
• Biomolekyl盲ra interaktioner, s盲rskilt av transienta
• L盲kemedelsforskning s盲rskilt screeningtekniker
• Cellodlingstekniker
• Antibiotikaforskning
• Bioentrepreneurskap

1. Anandalakshmi V, Duong-Thi M-D, Pervushin K, Ohlson S and Mehta JS (2020) Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy. Journal of Advanced Research 24:529-543. .

2. Ohlson S and Duong-Thi M-D (2018) Fragment screening for drug leads by weak affinity chromatography (WAC-MS). Methods 14:26-38. .

3. Ohlson S, Kaur J, Raida M, Niss U, Bengala T, Drum CL, Boehm B and Torres AR (2017) Direct analysis – no sample preparation – of bioavailable cortisol in human plasma by weak affinity chromatography (WAC). Journal of Chromatography B 1061-1062:438-444. .

4. Singh P, Madhaiyan K, Duong-Thi MD, Dymock BW and Ohlson S (2017) Analysis of Protein Target Interactions of Synthetic Mixtures by Affinity-LC/MS. SLAS Discovery 22:440-446. .

5. Ohlson S and Duong-Thi M-D (2017) Weak Affinity Chromatography (WAC). In: Huddler D and Zartler ER (eds) Applied Biophysics for Drug Discovery, John Wiley & Sons, Ltd, pp. 107-130. .

6. Yao L, Mustafa N, Tan EC, Poulsen A, Singh P, Duong-Thi M-D, Lee JXT, Ramanujulu PM, Chng WJ, Yen JJY, Ohlson S and Dymock BW (2017) Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat. J. Med. Chem. 60:8336-8357. .

7. Ohlson S and Duong-Thi M-D (2016) Emerging technologies for fragment screening. In: Erlanson DA and Jahnke W (eds) Fragment-based Drug Discovery: Lessons and Outlook, First edition edn. Wiley-VCH Verlag, Weinheim, Germany pp. 173-195. .

8. Ohlson S (2008) Designing transient binding drugs: A new concept for drug discovery. Drug Discovery Today 13:433-439. .

9. Johansson L, Klinth J, Holmqvist O and Ohlson S (2003) Platelet Lysate: A Replacement for Fetal Bovine Serum in Animal Cell Culture. Cytotechnology 42:67-74. .

10. Zopf D and Ohlson S (1990) Weak-affinity Chromatography. Nature 346:87-88. .